Gerald Kerkut Trust Symposium
17th November 2021
Chilworth Manor
This was a day-long symposium during which postgraduates funded by the trust gave talks on their work. More images.
Programme
| Coffee | 08:30 - 09:00 |
| Welcome and introduction from Prof. Robert Walker | 09:00 - 09:15 |
 Ellie Seaby (2) (Sarah Ennis, Heidi Rehm)Objective targeting of de novo loss of function variants in constrained genes improves diagnostic rates |
09:15 - 09:30 |
| Brad Richardson (2) (Amrit Mudher, Herman Wijnen) How does the neuronal microtubular cytoskeleton age? Does this contribute to disease vulnerability? |
09:30 - 09:45 |
| Lucy Scullard (2) (Vincent O'Connor, Katrin Deinhardt) The Cysteine String Protein α PARADIGM: Synaptic proteostasis for neuronal stability in health and disease. |
09:45 - 10:00 |
| Naomi Thorne (2) (David Tumbarello, Roxana Carare) Investigating mitochondrial derived vesicles and their relationship to Parkinson’s pathology |
10:00 - 10:15 |
| Jacob Trend (3) (Claire Clarkin, Katrin Deinhardt, Phillip Schneider) Does common aetiology between Alzheimer’s disease and osteoporosis exist? |
10:15 - 10:30 |
| Coffee | 10:30 - 11:15 |
| Chair Dr Niall Horn | |
| Michael Price (3) (Herman Wijnen, Mariana Vargas-Caballero) Light mediated switching of circadian pacemaker function across the neural clock circuit of Drosophila |
11:15 - 11:30 |
| Kathryn Hussey (3) (Hannah Siddle, Edd James, Emma Reeves) Investigating the role of MHC class I molecules in immune evasion by tumour cells |
11:30 - 11:45 |
| Lloyd Steele-Nicholson (3) (Melissa Andrews, David Tumbarello) Microvesicular delivery of alpha9 integrin stimulates neurite outgrowth. |
11:45 - 12:00 |
| Laura Cooke (3) (Jane Cleal, Jaswinder Sethi, Pam Mahon, Nicholas
Harvey) Mechanisms of cellular vitamin D uptake |
12:00 - 12:15 |
| Lunch | 12:15 - 14:00 |
| Chair Dr Alan Thomas | |
| Dawn Cooper (4) (Matthew Loxham, Emily Swindle, Damon Teagle) Investigating the effects of combined exposures to airborne house dust mite and particulate matter on bronchial epithelial cells. |
14:00 - 14:15 |
| Monica Guerrero-Carrasco (4) (Diego Gomez-Nicola, Mariana Vargas- C Caballero) Understanding the role of pre-conditioning inflammation on the onset of Alzheimer's Disease. |
14:15 - 14:30 | Dianne Lopez (4) (Katrin Deinhardt, Mark Coldwell, Jonathan West) Investigating tau propagation in neuronal networks |
14:30 - 14:45 |
| Hannah Warming (4) (Mariana Vargas-Cabalerro, Ian Galea, Diederik Bulters) Haemoglobin toxicity and synaptic recovery in subarachnoid haemorrhage stroke |
14:45 - 15:00 |
| Tea | 15:00 - 15:45 |
| Chair Dr Alan Thomas | |
| Lauren McNicholas (4) (Katrin Deinhardt, Mariana Vargas-Caballero) Can Src Family Kinase inhibition rescue synaptic dysfunction in a mouse model of early Alzheimer's Disease? |
15:45 - 16:00 |
| Rebecca Carter (4) (Lorraine Williams) Investigating Zn homeostasis in the crop plant barley using CRISPR/Cas9 gene editing |
16:00 - 16:15 |
| Steve John (4) (Matthias Baud, Rob Ewing, Graham Packham, Paul Skipp) Small molecular modulation of the Wnt Pathway: A focus on B-catenin and Interactions |
16:15 - 16:30 |
| Ben Bachelor (4) (Amrit Mudher) Developing a Drosophila-based model in which to study aspects of pathological Tau transfer |
16:30 - 16:45 |
| Brief discussion concerning the Trust’s future activities | 16:45 |
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